Martin Arrowsmith's clinical trial: scientific precision and heroic medicine

Martin Arrowsmith's clinical trial: scientific precision and heroic medicine.

Heroic Medicine

Nearly 60 years after he died, surgeons from around the world still honour the memory of Sir Robert Jones, the father of modern British orthopaedics. Sir Robert lived and worked at a time when crippled children were a common sight on Britain's streets, and one of his greatest achievements was to show that many of these children-the victims chiefly of tuberculosis, rickets, and poliomyelitis-cou...

Precision medicine, technologies, and molecular diagnostics

Introduction: Genetics, cellular and molecular medicines are cutting-edge sciences and technologies that play an important role in improving human health and quality of life. In addition, medical and biological sciences have clearly shown that the onset of diseases differs from person to person due to their different genetic profiles and variations in molecular basis. Therefore, it is feasible ...

Bioinformatics for precision medicine in oncology: principles and application to the SHIVA clinical trial

Precision medicine (PM) requires the delivery of individually adapted medical care based on the genetic characteristics of each patient and his/her tumor. The last decade witnessed the development of high-throughput technologies such as microarrays and next-generation sequencing which paved the way to PM in the field of oncology. While the cost of these technologies decreases, we are facing an ...

A Hybrid Approach to Precision Medicine-related Biomedical Article Retrieval and Clinical Trial Matching

We describe our systems implemented for the Text Retrieval Conference (TREC 2017) Precision Medicine track. We submitted five runs for biomedical article retrieval and five runs for clinical trial matching. Our approaches combine strict rule matching with an ontology-based solution. Evaluation results demonstrate that our best run obtained the 2nd highest precision (P@5) score for the clinical ...